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The future of sustainable human health and agriculture rests on our ability to view microbial evolution as part of the solution rather than the problem. JiYe Men's Running shoes Outdoors Lace Up Fashion SneakersThe Koskella lab takes on this challenge by combining discovery-based science on plant microbiomes with hypothesis-driven experimentation. Our research examines host-microbe and microbe-microbe interactions by first identifying patterns in nature and then, in line with current theory where available,Phil Betty Mens Booties Warm Zipper Non-Slip Breathable Wear-Resistant Casual Martin BootsMen's Deck shoes, New Mens Leather shoes Fashion Casual Sneakers Korean Version British shoes (color Black, Size 38) NXT NEW YORK Leather Men Dress shoes Plain Toe Slip On Loafer shoes Comfortable Classic Formal Business shoesL'Artiste by Spring Step Womens Pricilla Heeled Sandalgenerating predictions to explicitly test in the laboratory using a combination of experimental evolution, microbial ecology approaches, Texcy Luxe]Leather Lightweight Oxfords Men shoes Lace-Up Black 25.5and molecular biological techniques.
We focus primarily on how plant-microbiome, plant-pathogen, and bacteria-phage interactions occur, both as model systems for understanding fundamental principles and with the aim of leveraging these findings for design of novel disease management strategies. Miz Mooz Womens Lauralyn LoaferPleaser Women's Bejeweled 708MS Ankle Strap SandalsWe integrate ecological and evolutionary thinking with cutting-edge microbiological and molecular approaches to gain insight to microbiome establishment and function, within-microbiome interactions, and the role that microbiota and phages play in shaping disease. For more information on ongoing research projects, look here.
The Koskella lab at our end-of-semester lab lunch (May 2019)
A brief introduction to the lab and our recent research:
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I am an evolutionary ecologist interested in how species interactions influence genetic diversity within populations, diversity between populations, and species diversity at the community level. By combining evolutionary theory on coevolution, population dynamics, and infection genetics,BIMUDUIYU Men's Business Dress Loafers Pointy Black Oxford shoesItalian Mens shoes Casual Brands Genuine Leather Men Loafers Luxury Moccasins Comfy Breathable Slip On Boat shoes MenNicholas Deakins Botang Desert Mens shoesOfficial Ben Sherman Gustarvo Trainers Mens Athleisure Footwear shoes Sneakers I directly test the underlying assumptions and predicted outcomes of host-pathogen and microbial interactions through the lens of human health and agricultural sustainability.
My previous work was primarily focused on host – parasite coevolution; first between a smut fungus and a plant (e.g. QUTAA Leather Women Over The Knee Boots), then a trematode and a snail (e.g. MCRAE Industrial Men's Steel Toe Metatarsal Guard Lace Up Work Boot), and most recently between bacteriophage viruses and the bacteria they infect, which are themselves parasites of plants (e.g. if phages are locally adapted to bacteria, Aerosoles Womens Martha Stewart Pilot Slide Sandaland Columbia Womens HeavenlyTM Shorty Omni-heatTM Ankle Boot). The types of fundamental questions I’ve address are:
1) How do pathogens/parasites adapt to better infect their hosts? And at what scale / speed are they capable of adapting?
Meaden, S., & Koskella, B. (2017). Adaptation of the pathogen, Pseudomonas syringae, Roper Western Cowbabies Billy Boys 3 Infant Tan 09-016-1900-0079 BRDesi Hangover Genuine Premium Leather Handmade Mens Casual shoes Slip-on Loafers Hola Red shoes, Free Express Shippingduring experimental evolution on a native vs. alternative host plant. Molecular ecology, 26(7), 1790-1801.
Koskella, B. (2014). Bacteria-phage interactions across time and space: merging local adaptation and time-shift experiments to understand phage evolution. The American Naturalist, 184(S1), S9-S21.
Koskella, B., Thompson, J. N., Preston, G. M., & Buckling, A. (2011). Diesel Men's Eastcop Starch Fashion SneakerNike Men's Air Max Dynasty 2 Ankle-High Running shoesLocal biotic environment shapes the spatial scale of bacteriophage adaptation to bacteria. The American Naturalist, 177(4), 440-451.
Greischar, M. A., & Koskella, B. (2007). A synthesis of experimental work on parasite local adaptation. Ecology Letters, 10(5), 418-434.
2) How do hosts respond to this adaptation (i.e. coevolve) and become more resistant to their local pathogens/parasites? Amblers Safety Mens AS200 Skiddaw Pull on Dealer Safety Boot Brown Size UK 6 EU 39Rock Fall Pro Man Seattle S1P SRC bluee Yellow Steel Toe Cap Boxing Safety BootsAnd are they paying a significant cost for this evolved resistance?Adidas Men's Ligra 5 Volleyball shoesD.A.T.E. (DATE) Fashion-Sneakers Mens Green.
Koskella, B., & Parr, N. (2015). The evolution of bacterial resistance against bacteriophages in the horse chestnut phyllosphere is general across both space and time. Phil. Trans. R. Soc. B, 370(1675), 20140297.
Meaden, S., Paszkiewicz, K., & Koskella, B. (2015). The cost of phage resistance in a plant pathogenic bacterium is context‐dependent. Evolution, 69(5), 1321-1328.
Koskella, B. (2013). Phage-mediated selection on microbiota of a long-lived host. Current Biology, 23(13), 1256-1260.
Koskella, B., Lin, D. M., Buckling, A., & Thompson, J. N. (2011).Desai Men’s Business Casual Formal shoes Lace Up Genuine Leather Derby shoesMens Oxford shoes Lace-Up Pull-On Pointed Toe Breathable Business Formal shoes Franco Vanucci Vince & Maurizio Men's Texture Casual OxfordJosef Seibel Anvers 34 Mens Camel Fisherman Sandal (45 EU)The costs of evolving resistance in heterogeneous parasite environments. Proceedings of the Royal Society of London B: Biological Sciences, rspb20112259.
3) Can antagonistic coevolution lead to increased diversity? For example, do pathogens/parasites preferentially target common hosts (i.e. the hosts that are the most fit) and therefore impose a rare-host advantage?
Morella, N. M., Gomez, A. L., Wang, G., Leung, M. S., & Koskella, B. (2018). The impact of bacteriophages on phyllosphere bacterial abundance and composition. Molecular ecology, 27(8), 2025-2038.
Koskella, B., & Lively, C. M. (2009). Evidence for negative frequency‐dependent selection during experimental coevolution of a freshwater snail and a sterilizing trematode. Evolution: International Journal of Organic Evolution, 63(9), 2213-2221.
and 4) Does this coevolution among hosts and parasites matter to human health, agriculture, and conservation? Can we use our understanding about when and how pathogens and commensals evolve to design better treatments and to predict and prevent the spread of diseases?
Koskella, B., & Taylor, T. B. (2018). Multifaceted impacts of bacteriophages in the plant microbiome. Annual review of phytopathology, 56, 361-380.
Lin, D., & Koskella, B. (2015). Friend and foe: Eclimb Men's Womens Waterproof Leather Work Boots Steel Toe Safety shoesWeiPoot Women's Blend Materials Solid Closed-Toe Boots with Platform and Slipping Solefactors influencing the movement of the bacterium Helicobacter pylori along the parasitism–mutualism continuum. Evolutionary applications, 8(1), 9-22.
Meaden, S., & Koskella, B. (2013). Exploring the risks of phage application in the environment. Frontiers in microbiology, 4, 358.
So far, the body of evidence produced by the scientific community over decades of work suggests that parasites can evolve rapidly and specifically to infect their hosts, but that this doesn’t always mean they get more harmful or even better at infecting.Bill Blass Womens Sylvie Flat SandalBONGZUO Oxford shoes, Men Leather Brushed Oxford shoes Business Dress Up Pointed England Men shoes 2018 Autumn, YMHS03-WJ3 There is also clear evidence that hosts respond by evolving increased resistance, and that this often comes at a cost such as decreased growth or reproduction. This ongoing coevolution, in which neither parasite nor host is winning the battle has been called ‘Red Queen’ dynamics, based on the idea from “Alice Through the Looking Glass” that you have to run as fast as you can just to stay in the same placeSpring New Lace Solid color Korean Fashion shoes Flat Casual Joker Men's shoes XIAOQIUirend Speed-Laces Combat Boots Unisex Adults - Outdoor Indoor Low-Top Trekking Sneaker Classic Lightweight Military Hiking Fitness Climbing Boots.T.U.K. Unisex V6804 Creeper OxfordNew Balance Women's W560V6 Running shoes At last these ideas are beginning to be incorporated into the design and use of drug treatments (sometimes referred to as Darwinian Medicine) and used to build predictive models of disease spread in our increasingly-connected world. My work has taken advantage of a very powerful approach to address these questions by experimentally evolving hosts and parasites in the laboratory, Kenneth Cole REACTION Mens Stop Drop N Roll Combat BootPepe Jeans Men's Tourist -Er Print Espadrillestherefore controlling for all the other “noise” out there in nature (Defeet Skull Caps Single Ply Thin Toboggan Liner Inside Helmet Socks).Morris Costumes HAG105BKMD Gotham 105 Black Md 10-11Nike Mens Meadow 16 LTR Leather Low Top Lace Up Running Sneaker However,DESAI Men' s Handmade Premium Genuine Leather Slip-on shoes Loafers Business OxfordsFSJ Men's Formal Oxford Dress shoes Slip On Loafers Flats Shiny Patent Leather Size 7-14 US I always try to go back to nature’s microcosm to find out whether what holds true in the lab can be used to explain what we see in the real world.Kenneth Cole Men's Kam Sneakers in Black