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The future of sustainable human health and agriculture rests on our ability to view microbial evolution as part of the solution rather than the problem. Women's Chelsea Boots, 2019 Autumn Winter New Leather Ankle Boots, Female Stiletto Pointed Boots, Ladies Simple Single Boots, Casual shoes (color Black, Size 42)The Koskella lab takes on this challenge by combining discovery-based science on plant microbiomes with hypothesis-driven experimentation. Our research examines host-microbe and microbe-microbe interactions by first identifying patterns in nature and then, in line with current theory where available,Jordan Aj10 I'm Back' Tee Mens Style 944224Gentle Souls Womens Chantel-la Mid-Heel Slip on Mule Heeled Sandal So8ooa Lady Slippers Ladies Casual Wool Slippers Indoors to Keep Warm in Autumn and Winter Slippers for Women Black and White CuteCALTO - G3330-4 Inches Taller - Height Increasing Elevator shoes (Black High-top Lace-up Sneakers)generating predictions to explicitly test in the laboratory using a combination of experimental evolution, microbial ecology approaches, Le Coq Sportif Dynacomf Poke, Unisex Adults’ Trainersand molecular biological techniques.
We focus primarily on how plant-microbiome, plant-pathogen, and bacteria-phage interactions occur, both as model systems for understanding fundamental principles and with the aim of leveraging these findings for design of novel disease management strategies. Corkys Annabel Women's Boot 11 B(M) US GreyCaterpillar Men's Rangler MR 8 Steel Toe Work BootWe integrate ecological and evolutionary thinking with cutting-edge microbiological and molecular approaches to gain insight to microbiome establishment and function, within-microbiome interactions, and the role that microbiota and phages play in shaping disease. For more information on ongoing research projects, look here.
The Koskella lab at our end-of-semester lab lunch (May 2019)
A brief introduction to the lab and our recent research:
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I am an evolutionary ecologist interested in how species interactions influence genetic diversity within populations, diversity between populations, and species diversity at the community level. By combining evolutionary theory on coevolution, population dynamics, and infection genetics,Elegant Breathable Roll Up shoes Can Foldable Women Flat Casual shoes Work shoes ( color Black , Size 37 )Adidas Ace 17.1 Leather FG Mens Firm Ground Soccer Boots CleatsGerry Weber Women Pumps Matera 02 Pink, (Fuchsia) G96402886 430LACROSSE Insulated Pac 12 Height OD Green (260040) Waterproof Insulated Modern Comfortable Hunting Combat Boot I directly test the underlying assumptions and predicted outcomes of host-pathogen and microbial interactions through the lens of human health and agricultural sustainability.
My previous work was primarily focused on host – parasite coevolution; first between a smut fungus and a plant (e.g. Kappa Womens Authentic Asper Hoodie - Black White - LG), then a trematode and a snail (e.g. Women's Fashion shoes Chelsea Booties Spring Autumn British Leather Martin Boots Flower Pattern Pointed High Heel Boots Ankle Boots (color A, Size 35)), and most recently between bacteriophage viruses and the bacteria they infect, which are themselves parasites of plants (e.g. if phages are locally adapted to bacteria, Nike Womens Roshe One Lx Low Top Lace Up Fashion Sneakersand Women's Snow Boots Flat Heel Ankle Boots Winter Warm Rhinestone for Ladies Outdoor 2018). The types of fundamental questions I’ve address are:
1) How do pathogens/parasites adapt to better infect their hosts? And at what scale / speed are they capable of adapting?
Meaden, S., & Koskella, B. (2017). Adaptation of the pathogen, Pseudomonas syringae, Rieker Girls' The Boat Gerta Knows Leder Fashion SneakersGabor Women Sandals Black, (black (Strass)) 42.843.97during experimental evolution on a native vs. alternative host plant. Molecular ecology, 26(7), 1790-1801.
Koskella, B. (2014). Bacteria-phage interactions across time and space: merging local adaptation and time-shift experiments to understand phage evolution. The American Naturalist, 184(S1), S9-S21.
Koskella, B., Thompson, J. N., Preston, G. M., & Buckling, A. (2011). Loeffler Randall Womens Lexi Dress PumpSteve Madden Women's Holster BootieLocal biotic environment shapes the spatial scale of bacteriophage adaptation to bacteria. The American Naturalist, 177(4), 440-451.
Greischar, M. A., & Koskella, B. (2007). A synthesis of experimental work on parasite local adaptation. Ecology Letters, 10(5), 418-434.
2) How do hosts respond to this adaptation (i.e. coevolve) and become more resistant to their local pathogens/parasites? Nine Seven Women's Genuine Leather Pointed Toe High Exquisite Heel Side Zip Handmade Graceful Ankle BootiesHummel Unisex Adults' Victory Low-Top Sneakers, Light bluee White, 8 UKAnd are they paying a significant cost for this evolved resistance?Women's Slim Belt Open Toe Sandals Wrap Belt Buckle High Heels Shiny Rhinestones Fashion Sandals (Heel Height 12 cm)MINIVOG Almond Toe Flat Platform Womens Loafer shoes.
Koskella, B., & Parr, N. (2015). The evolution of bacterial resistance against bacteriophages in the horse chestnut phyllosphere is general across both space and time. Phil. Trans. R. Soc. B, 370(1675), 20140297.
Meaden, S., Paszkiewicz, K., & Koskella, B. (2015). The cost of phage resistance in a plant pathogenic bacterium is context‐dependent. Evolution, 69(5), 1321-1328.
Koskella, B. (2013). Phage-mediated selection on microbiota of a long-lived host. Current Biology, 23(13), 1256-1260.
Koskella, B., Lin, D. M., Buckling, A., & Thompson, J. N. (2011).Adidas Prophere Womens in Clear Mint Solar Red, 6Kodiak Men's K4 Trail-10 Fire and Safety shoes Construction Saucony Sneakers Jazz Original Grey and Purple, Womens.English Laundry Mens Dylan LoaferThe costs of evolving resistance in heterogeneous parasite environments. Proceedings of the Royal Society of London B: Biological Sciences, rspb20112259.
3) Can antagonistic coevolution lead to increased diversity? For example, do pathogens/parasites preferentially target common hosts (i.e. the hosts that are the most fit) and therefore impose a rare-host advantage?
Morella, N. M., Gomez, A. L., Wang, G., Leung, M. S., & Koskella, B. (2018). The impact of bacteriophages on phyllosphere bacterial abundance and composition. Molecular ecology, 27(8), 2025-2038.
Koskella, B., & Lively, C. M. (2009). Evidence for negative frequency‐dependent selection during experimental coevolution of a freshwater snail and a sterilizing trematode. Evolution: International Journal of Organic Evolution, 63(9), 2213-2221.
and 4) Does this coevolution among hosts and parasites matter to human health, agriculture, and conservation? Can we use our understanding about when and how pathogens and commensals evolve to design better treatments and to predict and prevent the spread of diseases?
Koskella, B., & Taylor, T. B. (2018). Multifaceted impacts of bacteriophages in the plant microbiome. Annual review of phytopathology, 56, 361-380.
Lin, D., & Koskella, B. (2015). Friend and foe: Naturalizer HARMONY E8953F1001 Black Fabric Print (9 Wide)Women Boots with Chunky Heel Classical Half Boots Zipper shoes Low Heel Zipper Booties Black for Fall Winterfactors influencing the movement of the bacterium Helicobacter pylori along the parasitism–mutualism continuum. Evolutionary applications, 8(1), 9-22.
Meaden, S., & Koskella, B. (2013). Exploring the risks of phage application in the environment. Frontiers in microbiology, 4, 358.
So far, the body of evidence produced by the scientific community over decades of work suggests that parasites can evolve rapidly and specifically to infect their hosts, but that this doesn’t always mean they get more harmful or even better at infecting.Women's Leather Boots, European American Style Springtime Increased Casual Booties High Heel Women's Boots Flat Single Boot (color A, Size 34)Women's shoes Leather Spring Summer Loafers & Slip-Ons Driving shoes Sneakers Comfort Walking shoes Athletic Breathable Casual Outdoor Formal Business Work (color B, Size 37) There is also clear evidence that hosts respond by evolving increased resistance, and that this often comes at a cost such as decreased growth or reproduction. This ongoing coevolution, in which neither parasite nor host is winning the battle has been called ‘Red Queen’ dynamics, based on the idea from “Alice Through the Looking Glass” that you have to run as fast as you can just to stay in the same placeWetrics Mens Basketball shoes Womens Fashion Sneakers Running Boots Non-Slip SoleT-JULY Fashion Cow Suede Stockings Autumn Winter Stretch Boots Mid Heels Round Toe Crystal Heels Women Over The Knee Boots.Richter Jungen Stiefel grey (9)EileenFisher Womens Tall Knee High Boot At last these ideas are beginning to be incorporated into the design and use of drug treatments (sometimes referred to as Darwinian Medicine) and used to build predictive models of disease spread in our increasingly-connected world. My work has taken advantage of a very powerful approach to address these questions by experimentally evolving hosts and parasites in the laboratory, Women 's winter snow boots bowknot thickening warm hairy fluffy boots fashion leather short boots ( color Black , Size US 5\UK 4\EUR 35 )Easy Spirit Women's Traveltime 142 Black Black S009 10 AA UStherefore controlling for all the other “noise” out there in nature (Blowfish Women's Frizbee Off-White Sand Dune 7 M US).T-JULY Women Winter Knee-High Boots Pointed Toe Thin High Long Heels Western Sexy Style shoesFly London Women's Luz Boot However,Ted Baker Womens Liveca Chelsea BootClarks Wave Andes - Black Nubuck (See Description for Size) I always try to go back to nature’s microcosm to find out whether what holds true in the lab can be used to explain what we see in the real world.Clarks Originals Desert London Dress shoes